Translational Research Group on Pediatric Solid Tumors

Oncology Area

Genomic heterogeneity in neuroblastoma (NB)

3D in vitro and xenotransplant models of NB

Importance of extracellular matrix and stroma cells (including immune cells) in tumors

Morphological and molecular analysis of neuroblastic and malignant infantile skeletal tumors

Coordinatora
Dr. Samuel Navarro Fos
samuel.navarro@uv.es; navarro@uv.es

Coordinatora
Dra. Rosa Noguera Salvá
rosa.noguera@uv.es  

RESEARCHERS
Leading, R4

Rosa Noguera Salvá    
Samuel Navarro Fos    

Established, R3

Inmaculada Noguera Salvá

Recognised/Emerging, R2

Ezequiel Monferrer Garzarán
José Jaime Verdú Amorós
Mª Amparo López Carrasco
Sofía Granados Aparici

First Stage, R1

Isaac Vieco Martí

STAFF
Collaborating Researchers

Amparo Compañ Quilis
Mara Stoks
Marta Gómez Rebolledo

Nurse
Technicians
Administrative assistant
Publications
Solitary fibrous tumor: can the new Huang risk stratification system for orbital tumors improve prognostic accuracy in other tumor locations?. Medina-Ceballos E, Machado I, Giner F, Bujeda A, Navarro S, Ferrandez A, Lavernia J, Ruiz-Sauri A, Llombart-Bosch A. Pathology, Research and Practice. 2024 Feb:254:155143. doi: 10.1016/j.prp.2024.155143. PMID: 38301364

Acquired aggressive multisystemic disseminated lobular capillary haemangioma: a life threatening disorder. Monteagudo C, Porcar-Saura S, Navarro S, Burgues O, Gonzalez J, Ferrandez A, Forner M. Pathology. 2023 Aug;55(5):729-732. doi: 10.1016/j.pathol.2022.11.014. PMID: 36894353

Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine. Salek M, Mueller A, Alanbousi I, Cepowska Z, Dutkiewicz M, Earl J, Evseev D, Kizyma R, Kliuchkivska K, Kolodrubiec J, Matczak K, Nogovitsyna Y, Oszer A, Pogorelyy M, Raciborska A, Rasul S, Sokolowski I, Sopilnyak A, Vinitsky A, Wlodarski M, Wobst N, Yakimkova T, Rodriguez-Galindo C, Wise P, Mlynarski W, Agulnik A. Lancet Oncology. 2023 Dec;24(12):1315-1318. doi: 10.1016/S1470-2045(23)00456-4. PMID: 38039989

Digital image analysis workflows for evaluation of cell behavior and tumor microenvironment to aid therapeutic assessment in high-risk neuroblastoma. Stoks M, Vieco-Marti I, Noguera I, Sanchez-Sanchez M, Burgos-Panadero R, Navarro S, Noguera R. Computers in Biology and Medicine. 2023 Aug 14;164:107364. doi: 10.1016/j.compbiomed.2023.107364. PMID: 37598482

Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial. Alexander S, Auperin A, Bomken S, Csoka M, Kazanowska B, Chiang A, Andres M, Uyttebroeck A, Burke G, Zsiros J, Pillon M, Bollard C, Mussolin L, Verdu-Amoros J, Neven B, Barkauskas D, Wheatley K, Patte C, Gross T, Minard-Colin V. Lancet. Haematology. 2023 Jun;10(6):e445-e457. doi: 10.1016/S2352-3026(23)00062-5. PMID: 37094596

Extra-meningeal solitary fibrous tumor: an evolving entity with chameleonic morphological diversity, a hallmark molecular alteration and unresolved issues in risk stratification assessment. Machado I, Giner F, Cruz J, Lavernia J, Marhuenda-Fluixa A, Claramunt R, Lopez-Guerrero J, Navarro S, Ferrandez A, Blazquez Bujeda A, Ruiz-Sauri A, Llombart-Bosch A. Histology and Histopathology. 2023 Oct;38(10):1079-1097. doi: 10.14670/HH-18-608. PMID: 36975173

Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome – an immunohistochemical and molecular analysis of 31 cases. Giner F, Lopez-Guerrero J, Machado I, Rubio-Martinez L, Espino M, Navarro S, Agra-Pujol C, Ferrandez A, Llombart-Bosch A. Virchows Archiv. 2023 Feb;482(2):407-417. doi: 10.1007/s00428-022-03453-x. PMID: 36376703

Haploidentical vs. HLA-matched donor hematopoietic stem-cell transplantation for pediatric patients with acute lymphoblastic leukemia in second remission: a collaborative retrospective study of the Spanish Group for Bone Marrow Transplantation in Children (GETMON/GETH) and the Spanish Childhood Relapsed ALL Board (ReALLNet). Moreno C, Ramos-Elbal E, Velasco P, Aguilar Y, Martinez B, Fuentes C, Molinos A, Guerra-Garcia P, Palomo P, Verdu J, Pedroso R, Vagace J, Lopez-Duarte M, Regueiro A, Tasso M, Dapena J, Salinas J, Navarro S, Bautista F, Lassaletta A, Lendinez F, Rives S, Pascual A, Rodriguez A, Perez-Hurtado J, Fernandez J, Perez-Martinez A, Gonzalez-Vicent M, de Heredia C, Fuster J. Frontiers in Pediatrics. 2023 Mar 20;11:1140637. doi: 10.3389/fped.2023.1140637. PMID: 37020654

Impact of pleural lavage cytology positivity on early recurrence after surgery for non-small cell lung cancer. Recuero Diaz J, Gatius Caldero S, Rosado Rodriguez J, Caamano Villaverde V, Gomez de Antonio D, Tejerina E, Sanchez Moreno L, Martino Gonzalez M, Moldes Rodriguez M, Abdulkader Nallib I, Ramirez Gil E, Amat Villegas I, Genoves Crespo M, Garcia Angel R, Sampedro Salinas C, Figueroa Almanzar S, Compan Quilis A, Saumench Perramon R, Gonzalez Pont G, Royo Crespo I, Gambo Grasa P, Garcia Fernandez J, Jimenez Heffernan J, Ceron Navarro J, Prieto Rodriguez M, Porcel J. Archivos de Bronconeumologia. 2023 Dec 18:S0300-2896(23)00402-7. doi: 10.1016/j.arbres.2023.12.001. PMID: 38238188

Intimal Sarcoma with MDM2/CDK4 amplification and p16 Overexpression: a review of histological features in primary tumor and xenograft, with immunophenotype and molecular profiling. Giner F, Machado I, Rubio-Martinez L, Lopez-Guerrero J, Claramunt-Alonso R, Navarro S, Ferrandez A, Mayordomo-Aranda E, Llombart-Bosch A. International Journal of Molecular Sciences. 2023 Apr 19;24(8):7535. doi: 10.3390/ijms24087535. PMID: 37108696

The value of GLI1 and p16 immunohistochemistry in the premolecular screening for GLI1-altered mesenchymal neoplasms. Machado I, Agaimy A, Giner F, Navarro S, Michal M, Bridge J, Claramunt R, López-Guerrero JA, Alcacer J, Linos K, Llombart-Bosch A. Virchows Archiv. 2023 Nov 8. doi: 10.1007/s00428-023-03687-3. PMID: 37940743

Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup. Martinez-Monleon A, Oberg H, Gaarder J, Berbegall A, Javanmardi N, Djos A, Ussowicz M, Taschner-Mandl S, Ambros I, Ora I, Sandstedt B, Beiske K, Ladenstein R, Noguera R, Ambros P, Murkes L, Ljungman G, Kogner P, Fransson S, Martinsson T. Scientific Reports. 2022 Jul 20;12(1):12420. doi: 10.1038/s41598-022-16455-1. PMID: 35859155

Does PAX7 and NKX2.2 immunoreactivity in Ewing sarcoma have prognostic significance?. Machado I, Charville GW, Yoshida A, Navarro S, Righi A, Gambarotti M, Scotlandi K, Lopez-Guerrero JA, Llombart-Bosch A. Virchows Archiv. 2022 Apr;480(4):909-917. doi: 10.1007/s00428-021-03254-8. PMID: 34985580

Evaluation of alternative risk stratification systems in a large series of solitary fibrous tumors with molecular findings and Ki-67 Index Data: do they improve risk assessment?. Machado I, Bujeda A, Giner F, Morales M, Cruz J, Lavernia J, Navarro S, Ferrandez A, Ruiz-Sauri A, Llombart-Bosch A. International Journal of Molecular Sciences. 2022 Dec 27;24(1):439. doi: 10.3390/ijms24010439. PMID: 36613891

Integrating digital pathology with transcriptomic and epigenomic tools for predicting metastatic uterine tumor aggressiveness. Sonzini G, Granados-Aparici S, Sanegre S, Diaz-Lagares A, Diaz-Martin J, de Andrea C, Eritja N, Bao-Caamano A, Costa-Fraga N, Garcia-Ros D, Salguero-Aranda C, Davidson B, Lopez-Lopez R, Melero I, Navarro S, Ramon Y Cajal S, de Alava E, Matias-Guiu X, Noguera R. Frontiers in Cell and Developmental Biology. 2022 Nov 18;10:1052098. doi: 10.3389/fcell.2022.1052098. PMID: 36467415

The complexity of cancer immunotherapy illustrated through skin tumors. Vieco-Marti I, Lopez-Carrasco A, de la Cruz-Merino L, Noguera R, Alvaro Naranjo T. International Journal of Biological Markers. 2022 Jun;37(2):113-122. doi: 10.1177/03936155221088884. PMID: 35473449

Vitronectin-based hydrogels recapitulate neuroblastoma growth conditions. Monferrer E, Dobre O, Trujillo S, Oliva M, Trubert-Paneli A, Acevedo-Leon D, Noguera R, Salmeron-Sanchez M. Frontiers in Cell and Developmental Biology. 2022 Oct 11;10:988699. doi: 10.3389/fcell.2022.988699. PMID: 36425532

A G316A polymorphism in the ornithine decarboxylase gene promoter modulates mycn-driven childhood neuroblastoma. Gamble L, Purgato S, Henderson M, Di Giacomo S, Russell A, Pigini P, Murray J, Valli E, Milazzo G, Giorgi F, Cowley M, Ashton L, Bhalshankar J, Schleiermacher G, Rihani A, Van Maerken T, Vandesompele J, Speleman F, Versteeg R, Koster J, Eggert A, Noguera R, Stallings R, Tonini G, Fong K, Vaksman Z, Diskin S, Maris J, London W, Marshall G, Ziegler D, Hogarty M, Perini G, Norris M, Haber M. Cancers. 2021 Apr 9;13(8):1807. doi: 10.3390/cancers13081807. PMID: 33918978

Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma. Sanegre S, Eritja N, de Andrea C, Diaz-Martin J, Diaz-Lagares A, Jacome MA, Salguero-Aranda C, Garcia Ros D, Davidson B, Lopez R, Melero I, Navarro S, Ramon y Cajal S, de Alava E, Matias-Guiu X, Noguera R. Frontiers in Cell and Developmental Biology. 2021 Jun 3;9:670185. doi: 10.3389/fcell.2021.670185. PMID: 34150764

Frequency and prognostic impact of alk amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1). Bellini A, Potschger U, Bernard V, Lapouble E, Baulande S, Ambros PF, Auger N, Beiske K, Bernkopf M, Betts DR, Bhalshankar J, Bown N, de Preter K, Clement N, Combaret V, Font de Mora J, George SL, Jimenez I, Jeison M, Marques B, Martinsson T, Mazzocco K, Morini M, Muhlethaler-Mottet A, Noguera R, Pierron G, Rossing M, Taschner-Mandl S, Van Roy N, Vicha A, Chesler L, Balwierz W, Castel V, Elliott M, Kogner P, Laureys G, Luksch R, Malis J, Popovic-Beck M, Ash S, Delattre O, Valteau-Couanet D, Tweddle DA, Ladenstein R, Schleiermacher G. Journal of Clinical Oncology. 2021 Oct 20;39(30):3377-3390. doi: 10.1200/JCO.21.00086. PMID: 34115544

Immunometabolism modulation in therapy. Monferrer E, Sanegre S, Vieco-Marti I, Lopez-Carrasco A, Farinas F, Villatoro A, Abanades S, Manes S, de la Cruz-merino L, Noguera R, Naranjo T. Biomedicines. 2021 Jul 9;9(7):798. doi: 10.3390/biomedicines9070798. PMID: 34356862

Integrated CGH/WES analyses advance understanding of aggressive neuroblastoma evolution: a case study. Corallo D, Zanon C, Pantile M, Tonini G, Zin A, Francescato S, Rossi B, Trevisson E, Pinato C, Monferrer E, Noguera R, Alino S, Herrero M, Biffi A, Viscardi E, Aveic S. Cells. 2021 Oct 9;10(10):2695. doi: 10.3390/cells10102695. PMID: 34685674

Intra-tumour genetic heterogeneity and prognosis in high-risk neuroblastoma. Lopez-Carrasco A, Berbegall A, Martin-Vano S, Blanquer-Maceiras M, Castel V, Navarro S, Noguera R. Cancers. 2021 Oct 15;13(20):5173. doi: 10.3390/cancers13205173. PMID: 34680323

Metabolic classification and intervention opportunities for tumor energy dysfunction. Monferrer E, Vieco-Marti I, Lopez-Carrasco A, Farinas F, Abanades S, de la Cruz-Merino L, Noguera R, Alvaro Naranjo T. Metabolites. 2021 Apr 23;11(5):264. doi: 10.3390/metabo11050264. PMID: 33922558

Neuroendocrine differentiation in a large series of genetically-confirmed Ewing’s sarcoma family tumor: Does it provide any diagnostic or prognostic information?. Machado I, Navarro S, Lopez-Guerrero J, Verdini L, Picci P, Giner F, Llombart-Bosch A. Pathology, Research and Practice. 2021 Feb 6;219:153362. doi: 10.1016/j.prp.2021.153362. PMID: 33610950

Solitary fibrous tumor: integration of clinical, morphologic, immunohistochemical and molecular findings in risk stratification and classification may better predict patient outcome. Machado I, Nieto Morales MG, Cruz J, Lavernia J, Giner F, Navarro S, Ferrandez A, Llombart-Bosch A. International Journal of Molecular Sciences. 2021 Aug 30;22(17):9423. doi: 10.3390/ijms22179423. PMID: 34502329

SuperHistopath: a deep learning pipeline for mapping tumor heterogeneity on low-resolution whole-slide digital histopathology images. Zormpas Petridis K, Noguera R, Ivankovic D, Kolarevic R, Jamin Y, Yuan Y. Frontiers in Oncology. 2021 Jan 20;10:586292. doi: 10.3389/fonc.2020.586292. PMID: 33552964

The oral KIF11 inhibitor 4SC-205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma models. Masanas M, Masia N, Suarez-Cabrera L, Olivan M, Soriano A, Majem B, Devis-Jauregui L, Burgos-Panadero R, Jimenez C, Rodriguez-Sodupe P, Boloix A, Toledano I, Guillen G, Navarro A, Llobet-Navas D, Villanueva A, Sanchez de Toledo J, Roma J, Noguera R, Moreno L, Krauss R, Gallego S, Santamaria A, Segura M. Clinical and Translational Medicine. 2021 Oct;11(10):e533. doi: 10.1002/ctm2.533. PMID: 34709738

Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma. Burgos-Panadero R, El Moukhtari SH, Noguera I, Rodriguez-Nogales C, Martin-Vano S, Vicente-Munuera P, Canete A, Navarro S, Blanco-Prieto MJ, Noguera R. International Journal of Pharmaceutics. 2021 Aug 28;608:121058. doi: 10.1016/j.ijpharm.2021.121058. PMID: 34461172

Projects
Reference: PMP21/00107
Title: INtegrative GENomic, digital Imaging and clinical information towars Precision Oncology Optimization – INGENIO
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Luis Paz-Ares Rodríguez
Duration: 2021 – 2024
Total budget: 3.780.700 €
Reference: IDIFEDER/2021/067
Title: Implantación de una plataforma de análisis genético de última generación para la investigación en genética biomédica
Funding body: Conselleria de Educación, Investigación, Cultura y Deporte
Principal Investigator: Rosa Noguera Salvá
Duration: 2021 – 2027
Total budget: 365.143 €
Reference: PRV00166
Title: Espacio intercelular: Bioimagen microscópica, Fase II
Funding body: Fundación Neuroblastoma
Principal Investigator: Rosa Noguera Salvá
Duration: 2021 – 2024
Total budget: 20.000 €
Reference: PI20/01107
Title: Neuroblastoma: estrategias mecanoterapéuticas basadas en modelos 3D y tumores derivados de pacientes con microambiente rico en vitronectina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rosa Noguera Salvá
Duration: 2021 – 2023
Total budget: 232.320 €
Reference: CASA-DP
Title: Cancer Stroma Assessment through Digital Pathology
Funding body: CIBERONC
Principal Investigator: Núria Malats
Duration: 2021 – 2023
Total budget: 90.000 €
Reference: 12/2019-P2Y01D
Title: Espacio intercelular: Bioimagen microscópica, Fase II
Funding body: Fundación Neuroblastoma
Principal Investigator: Rosa Noguera Salvá
Duration: 2019 – 2021
Total budget: 90.000 €
Reference: PI17/01558
Title: Identificación y validación de nuevas terapias, modelos preclínicos y marcadores de respuesta
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rosa Noguera Salvá
Duration: 2018 – 2020
Total budget: 123.420 €
Reference: CB16/12/00484
Title: CIBER Oncología (CIBERONC)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Rosa Noguera Salvá
Duration: 2017 –
Total budget: 360.000 €
+ Info
Title: Análisis de la expresión de las proteínas reparadoras del ADN mediante inmunohistoquímica en las biopsias endoscópicas y la pieza quirúrgica correspondiente de pacientes con cáncer colorrectal
Doctoral candidate: Martínez Lapiedra, Carmen
Director(s): Navarro Fos, Samuel; Machado Puerto, Isidro
Date of the defense: 19/05/2023
University: University de Valencia

Title: Transmisión de señales mecánicas en células indiferenciadas neuroblásticas. Estudios biológicos y preclínicos en modelos in vitro 3D
Doctoral candidate: Monferrer Garzarán, Ezequiel
Director(s): Noguera Salvá, Rosa
Date of the defense: 03/04/2023
University: Universitat de València

Title: Búsqueda de dianas terapéuticas en los puntos de contacto de la célula tumoral con su matriz extracelular en tumores neuroblásticos
Doctoral candidate: Burgos Panadero, Rebeca
Director(s): Noguera Salvá, Rosa; Navarro Fos, Samuel
Date of the defense: 31/07/2020
University: Universitat de València